Obstetric Vasculopathies: latest best-seller in Obstetrics & Gynecology world


 OBSTETRIC VASCULOPATHIES

 This book has already been proclaimed as a best-seller
within three days of its publication.
For buying this book click on: 
http://www.jaypeebrothers.com/MyShop/MyShop.aspx?ID=9789350904510

About the author:




Dr. Pankaj Desai is one of the best known academicians and teachers in Obstetrics and Gynecology in India. All his eight books have proved to be best-sellers, one of which was awarded the best book award in the subject. A prolific writer, he has contributed 38 chapters to different text books internationally and nationally. His outstanding academic contributions in the subject have been acknowledged and honored with 7 gold medals and 50 orations. An extremely popular teacher that he is, he has delivered 597 guest lectures in different parts of India and the world at the time of this book going for print. He has published 103 research papers till date, 9 of which have been awarded best research paper prizes. His website www.drpankajdesai.com has become an extremely popular portal for students and practitioners of the subject seeking references and up-to-date knowledge of the subject. It has invited more than 1, 50,000 hits by the time of this publication. His blogs on different academic and non-academic aspects being published on the net as Dr. Pankaj Desai's blogs have also become very popular inviting more than 14,000 reads as of now.

The contents outline of this book is thus:



1.     GENERAL ASPECTS OF OBSTETRIC VASCULOPATHIES

This chapter introduces the reader to the concept of obstetric vasculopathies and prepares a ground for understanding the approach to the different obstetric conditions listed under obstetric vasculopathies.

2.     CARDIOVASCULAR CHANGES IN NORMAL PREGNANCY

This chapter covers the normal physiological changes in CV system of a pregnant subject. Obstetric vasculopathies being a predominantly vascular condition this aspect of physiology is separately handled.

3.     IMMUNOLOGY OF OBSTETRIC VASCULOPATHIES

Immunology is now accepted to play a very important role in a healthy pregnancy outcome. Aberrations in immunological response can have profound effect on the pregnancy. Both alloimmune changes and autoimmune conditions affecting pregnancy clinically result as obstetric vasculopathies. This is extensively discussed in this chapter.

4.     ENDOTHELIAL CELL DYSFUNCTION & OBSTETRIC VASCULOPATHIES

Endothelial cell dysfunction is an important change in the series of events that take place in causation of obstetric vasculopathies. This chapter goes in depth of these changes and their clinical results.

5.     OXIDATIVE STRESS & OBSTETRIC VASCULOPATHIES

This chapter covers this critical aspect of etiopathology of obstetric vasculopathies. It explains what is oxidative stress, what is a free radical, oxidative stress and health, the mischief of free radicals in vascular walls, lipid peroxides as agents of oxidative stress, lipid metabolism in normal pregnancy and its bearings in abnormal pregnancy, placental lipid peroxidation, transition metals in lipid peroxidation, clinical manifestations of oxidative stress & obstetric vasculopathies, reperfusion damage in obstetric vasculopathies, role of innate maternal reducing systems, inefficient second wave of trophoblastic invasion and its bearings, VEGF in obstetric vasculopathies, nitric oxide in obstetric vasculopathies, placental atherosis in obstetric vasculopathies, extracellular reducing systems, uric acid: one of the most power house reductant, limitations of reducing systems, exercise & prevention of obstetric vasculopathies, treatment bearings and the beauty of lysophosphotidyl choline. 

6.     THE PLACENTA, THE TROPHOBLASTS AND OBSTETRIC VASCULOPATHIES

This chapter covers the basic process of normal placenta & placentation, role of oxygen tension in trophoblastic invasion, oxygenation and trophoblastic differentiation, faults in fetomaternal linkage at placenta & obstetric vasculopathies, maternal environment preventing trophoblastic invasion and bearings of these in obstetric vasculopathies.

7.     THE GENETICS OF OBSTETRICS VASCULOPATHIES

This chapter covers the basis for reviewing the role of genetics in obstetric vasculopathies, challenges to the genetic studies in obstetric vasculopathies, application of genetic models, examining associations of these models in obstetric vasculopathies, fetal contributions, immunology, genetics and epigenetic features in preeclampsia

8.     OBSTETRIC VASCULOPATHIES AND THEIR EFFECTS ON HEART

This chapter covers hemodynamics in normal pregnancy and during obstetric vasculopathies and effect of preeclampsia on the offspring besides covering the effects of obstetric vasculopathies on the heart

9.     OBSTETRIC VASCULOPATHIES AND THEIR EFFECTS ON THE RENAL SYSTEM

This chapter covers the vulnerability of renal system, special features of renal failure in obstetric vasculopathies, kidney lesions and doubts on veracity of “pathognomonic lesions”, gross changes in the kidneys, changes on microscopy, preeclampsia – a renal pathogenic model for understanding other forms of hypertension, renal function alterations, renal handing of proteins, handling of urinary excretion of proteins, renin-angiotensin system in obstetric vasculopathies in general and preeclampsia in particular.

10.   OBSTETRIC VASCULOPATHIES AND THEIR EFFECTS ON THE CENTRAL NERVOUS SYSTEM

Amongst the critical involvements of different systems and organs, CNS involvement seems to be more covert than overt in obstetric vasculopathies. This chapter covers the privileged status of CNS, pathological lesions in obstetric vasculopathies, effects on the brain and psychiatric complications following obstetric vasculopathies

11.   OBSTETRIC VASCULOPATHIES AND THEIR EFFECTS ON HEMATOLOGICAL SYSTEM

This chapter covers the alteration in coagulation factors (other than platelets) and procoagulants, alteration in other cellular components of blood, review of coagulation alterations in obstetric vasculopathies, platelets in normal and preeclamptic pregnancies, concept of competence alteration (efficiency) of platelets, platelet activation and thromboxane A2 production in obstetric vasculopathies

12.   OBSTETRIC VASCULOPATHIES AND THEIR EFFECTS ON THE LIVER

This chapter covers the pathological changes in the liver and liver in HELLP syndrome in reference to obstetric vasculopathies.

13.   OPHTHALMIC FEATURES IN OBSTETRIC VASCULOPATHIES

This chapter covers retinal edema, central and peripheral cause of visual alterations and visual alterations of special mention – recurrent and unilateral, in obstetric vasculopathies

14.   VASCULAR RESPONSES IN OBSTETRIC VASCULOPATHIES

This chapter covers blunted vascular response, placental ischemia, animal experiments in on this aspect of obstetric vasculopathies, dietary deficiency and animal experiments, quantification of fetomaternal interface vascular activity, salient results emerging from animal experiments, some intriguing observations from animal experiments, preeclampsia: a price for two legged humans, gene variation and preeclampsia, the exclusivity of human pregnancy and hard facts emerging from animal experiments vis-à-vis obstetric vasculopathies.

15.   CLINICAL PROFILE OF OBSTETRIC VASCULOPATHIES

This chapter covers hypertension, what BP is hypertension, concept of competence of reducing systems, proteinuria, edema, clinical bearings of laboratory parameters including understanding of plasma urea in obstetric vasculopathies

16.   DIFFERENTIAL DIAGNOSIS

This chapter covers conditions that require to be differentiated including preeclampsia and chronic hypertension, transient hypertension, renal diseases and hepato-hematological involvements

17.   PREDICTING OBSTETRIC VASCULOPATHIES

This chapter covers the amorphous characterizations of pathogenesis and clinical features, overview of the types of tests, negative to positive predictive value, conditions based tests, an ideal test, clinical tests including midtrimester B.P, the roll-over test, hand-grip test, weight gain, urinary tests including microalbuminuria, kallikrein, hematological cellular and non-cellular indices, platelet and platelet activation, platelet count and cd63 and uric acid in prediction of obstetric vasculopathies

18.   PREVENTION OF PREECLAMPSIA & OTHER OBSTETRIC VASCULOPATHIES

This chapter includes the difference between disease and derangement, preventing obstetric vasculopathy is a challenge, which subjects may benefit out of preventive measures prevent occurrence or prevent worsening, salt restriction, diuretics, antihypertensives, calcium supplementation, other trace elements like magnesium and zinc, preventive measures of obstetric vasculopathies, progesterone in prevention of obstetric vasculopathies, hCG in prevention of obstetric vasculopathies, antithrombotic agents (aspirin with or without heparin) for prevention of obstetric vasculopathies and prevention of eclampsia

19.   COLOUR DOPPLER IN OBSTETRIC VASCULOPATHIES

This chapter includes colour Doppler in early pregnancy, inconsistent notch, depth of the diastolic notch, colour Doppler indices in early pregnancy and its role in prediction, third trimester colour Doppler in obstetric vasculopathies, umbilical artery flow, middle cerebral artery, venous Doppler, limitations of venous Doppler, umbilical venous flow, venous Doppler for deciding the route of delivery, colour Doppler for discontinuation of antithrombotic agents, and fetal aortic Doppler studies in management of obstetric vasculopathies

20.   CARDIOTOCOGRAPHY (CTG) IN OBSTETRIC VASCULOPATHIES

This chapter includes physiology and CTG, hypoxia and FHR, CTG in subjects with APA Syndrome, colour Doppler and CTG correlation, the two together in preeclampsia, the two together in IUGR

21.   TREATMENT OF OBSTETRIC VASCULOPATHIES: RECURRENT MISCARRIAGES

In this chapter the role of folic acid, low dose aspirin including teratogenicity of aspirin, FAQs on aspirin, heparin, progesterone is treatment of immunological miscarriages, difficulties in interpreting scientific data, treatment of a subject of miscarriage always for prevention are discussed

22.   TREATMENT OF PREECLAMPSIA

In this chapter aspects related to limitations of blood pressures as an indicator of severity, early diagnosis and alert surveillance, do subjects of preeclampsia need admission, management on hospitalization, antihypertensives: which antihypertensive, challenges before any antihypertensive in PIH, monotherapy v/s multidrug therapy, dosage schedules, nifedipine, atenolol, labetalol, alpha methyldopa, hydralazine and when to stop antihypertensives, induction of labour in PIH: when to induce labour in PIH will be discussed

23.   MANAGEMENT OF OBSTETRIC VASCULOPATHIES: ACCIDENTAL HEMORRHAGE

In this chapter the etiopathology of accidental hemorrhage, the clinical effects of accidental hemorrhage, CTG changes in accidental hemorrhage, USG in accidental hemorrhage, obstetric management of accidental hemorrhage, why labour in accidental hemorrhage doesn’t follow the partogram, cesarean section in accidental hemorrhage and medical management of this obstetric vasculopathy will be discussed




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Comments

  1. ...as a layman all that I can comment is that it appears to be a detailed presentation of the subject matter...segmented thoughtfully in detail and gives an impression of a wholesome package of indept study, analysis and research which definitely would be a must know and a must have ready reckonner for practising gynaecologists as also for those teaching this subject line and needless to say for all those aspiring to be in the same platform as that of the author...
    ...outstanding and top class effort as always that has typically been as Dr PankajDesai's "Hallmark"...

    ReplyDelete
    Replies
    1. I am deeply touched Col. Sahab for your continuous blessings and encouragement. Like Ganesh you too have always been so happy with my happiness. I am touched Dada

      Delete
  2. Dear Dr Pankaj Desai, Congratulations! You have been an extraordinary teacher and the man we loved hearing to from the time of post graduation to till date. Wish you luck, good health and many more achievements! Looking forward to read more of your work and hear more of your talks!

    ReplyDelete
    Replies
    1. Thanks Monica. You are always very kind to me. Instead of giving myself reasons why I can’t, I give myself reasons why I can. Much encouraged.

      Delete
  3. Shruti Mehandale sent this message on the blog: Congratulations !! For the book and its success was reading blog updates on my reader saw your update ...its an honor to know you in personal way.

    ReplyDelete
  4. A hearty congratulations sir.......Will visit Baroda some day just to meet you......learn from you.Tell me please which part of year do you have time for students like me who haven't had the good fortune of meeting you personally?

    ReplyDelete
    Replies
    1. I would maintain that thanks are the highest form of thought, and that gratitude is happiness doubled by wonder. Thank You Kaushiki. i always have time for my students. I would be honoured.

      Delete
  5. Choosing the perfect OBGYN doctor plays a very important role in your entire pregnancy and in your birthing experience. Soon-to-be moms need to find an obstetrician who will be able to meet all their needs during their pregnancy.

    oB/GYN South Florida

    ReplyDelete
    Replies
    1. Very well said Micky. i absolutely agree with you. Thanks for your valuable comments. Much appreciated.

      Delete
  6. wishing you grand success. we are sure, it will be a very useful,handy reference book for the day to day problems.

    regards,

    dr.amee mehta
    dr.yogesh mehta.

    ReplyDelete
    Replies
    1. Deeply touched and encouraged by your good wishes Yogeshbhai and Ameeben

      Delete
  7. Pankaj
    Your persuation to pass on the information you have to the future generation, in this era of "flourishing Robotic Gynecologists" is an inspiration to me.
    keep up, Panakaj

    ReplyDelete
    Replies
    1. Thank you very much Sir. You have always encouraged me and this one is no exception. i am greatly honored your blessings

      Delete
  8. Its a good points and i agree with you and i got a good knowledge to read your informational post.

    The Best Gynecologist

    ReplyDelete
    Replies
    1. So nice of you Kavya. God Bless You

      Delete
  9. Dr. Suresh Sundar emailed this comment on this blog: Very well written blog, and it happens in so many places.

    ReplyDelete
  10. Prof Valsan from Kerala sent these comments via email: I got your book on Obstric Vasculopathies, last week. It gave me a lot of answers regarding the etiopathogenesis and management in IUGR. Really a fruitful reading last week.

    ReplyDelete
  11. Hi, I have just visited your site and the info you have covered has been of great interest
    to me. Some of the suggestions you have given have enabled me to apply my own thought
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    Gynecology instruments

    ReplyDelete
    Replies
    1. Thank you so much for such elaborate inputs. They are of great use to me. I am touched.

      Delete
  12. Nice blog. The credit goes to the Dr. Pankaj Desai who makes the Gynecology world days memorable forever.

    ReplyDelete
    Replies
    1. Thanks a million Dr. Sachin. I am greatly encouraged by your kind words.

      Delete
  13. At very first, congratulation to you!! What more I can say is that it's very important to go for a good obstetrics and gynaecology doctor for a women in her entire pregnancy as she need an obstetrician who will be able to meet all their needs during their pregnancy.

    Gynaecologist Melbourne

    ReplyDelete
    Replies
    1. Thank you very much Erin. I am much encouraged. I fully agree with your point of view.

      Delete
  14. I think it's not practical. If such a law imposed, in an emergency case, male doctors would be reluctant to consult females. The consequence will be fatal. May be even the death of patient.

    Nice and thought provoking post.
    Regards

    ReplyDelete

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